Abstract: Hydrogel-based microneedles (MNs) are revolutionising drug delivery by offering a minimally invasive, localised, and sustained release strategy with high therapeutic efficacy. Their inherent biocompatibility, high drug-loading capacity, and programmable degradation profiles make them ideal for advanced biomedical applications. The incorporation of Digital Light Processing (DLP) 3D printing enables precise fabrication of microneedles with complex geometries, optimised for controlled drug release.
This presentation features a novel case study: a 3D-printed GelMA-KerMA composite patch developed for the treatment of tympanic membrane perforations. These patches were enhanced with microneedle structures and further functionalised using electrohydrodynamic atomisation to deliver gentamicin and FGF-2-loaded PVA nanoparticles. In vitro studies confirmed potent antimicrobial activity and high biocompatibility, underscoring their promise for clinical applications.
The talk will explore the interface between hydrogel materials and advanced 3D printing for personalised medicine, highlighting design principles, fabrication strategies, and translational challenges.

Keywords: Hydrogel Microneedles, 3D Printing, Drug Delivery, GelMA, Tympanic Membrane, Tissue Engineering

Biography: Prof. Dr. Oguzhan Gunduz is the Director of the Center for Nanotechnology and Biomaterials Application and Research (NBUAM) at Marmara University, Istanbul, Turkey. He earned his Ph.D. in biomaterials and nanotechnology in 2013 from University College London (UCL), UK.
His academic career began in 2002 as a research assistant in materials technology at Marmara University. After completing his doctorate, he resumed his role at the university and has served as an academic staff member since 2017.
Prof. Gunduz has led numerous nationally and internationally funded projects in the fields of biomaterials, tissue engineering, drug delivery, and particle technologies. He has published over 300 peer-reviewed articles, 20 book chapters, and holds 10 patents related to biomaterials fabrication. His interdisciplinary research continues to make significant contributions to the development of innovative healthcare technologies.