Biography: Eddie is elected as:
* Academician for European Academy of Sciences (FEUAS, Greece);
* Fellow (inaugural) for National Academy of Technology (FNAT, USA);
*Academician for European Academy of Sciences and Arts (AEASA, EU-Austria);
* Fellow of the American Society of Mechanical Engineers (FASME, USA);
* Fellow of International Engineering and Technology Institute (FIETI, Hong Kong);
* Fellow of Asia-Pacific Technological Sciences Academy (FAPTSA, Hong Kong);
* Fellow of Institute of Engineering and Technology (FIET, United Kingdom);
* Distinguished Fellow for Institute of Data Science and Artificial Intelligence (DFIDSAI, China);
* Academician for Academy of Pedagogy and Learning (USA);
* Fellow of the American Institute for Medical and Biological Engineering (FAIMBE, USA) with his citation reads: "For outstanding contributions in non-contact, early detection of human-health abnormality non-invasively with infrared-physics-technology".

He has published numerous papers in SCI-IF int. journal (530); int. conf. proceedings (140), textbook chapters (>110) and others (32) over the 31 years. Co-edited 14 books in STEM areas.

He is in the Stanford list of the World’s top 2% Scientists since 2019 (ranked 173 as top 0.001% in the field of Biomedical Engineering), and ranked # 6 (Worldwide) in Google Scholar under Biomedical, cited by 18,050 (h-index: 68).

He is the:
* Lead Editor-in-Chief for the ISI Journal of Mechanics in Medicine and Biology for dissemination of original research in all fields of mechanics in medicine and biology since 2000;
* Founding Editor-in-Chief for the ISI indexed Journal of Medical Imaging and Health Informatics (2011-2021);
* Associate editor or EAB of various referred international journals such as Applied Intelligence, BioMedical Engineering OnLine, Sensors, Computers in Biology & Medicine, and, Journal of Advanced Thermal Science Research.
More details can be found in: Cv: https://dr.ntu.edu.sg/cris/rp/rp00847.

Ng obtained Ph.D. at Cambridge Univ. and elected as an Academician for European Academy of Sciences and Arts (Austria); Academician for European Academy of Sciences (Greece); a Fellow of The American Society of Mechanical Engineers; The Institution of Engineering and Technology [UK], and International Engineering & Technology Institute [HK]. He researches in numerical simulation in the biomedical engineering, thermal-fluids and health-related diagnosis fields. He is Editor-in-Chief for 2 ISI-journals which were captured by the JCR within 2-years of their inauguration. He has been recognized internationally for academic excellence. He received numerous best papers, service awards and has graduated 26 PhD and 26 Master students. He was awarded the SPRING-Singapore Merit Award for his work in thermal imagers to screen SARS fever and contributions to the Singapore Standardization Program. Twenty-one of his papers have been adopted as references in Singapore Standard (SS-582, Parts 1&2: 2020) and ISO/IEC 80601-2-59: 2017. He serves as a panel member for Singapore Biomedical and Health Standards Committee since 2011. Being a co-inventor of 3 US patents on software classifiers to identify the different stages of breast cancer development in iTBra-system, he was accoladed with equity in a listed company. His ongoing work on non-contact screening for carotid artery stenosis, superficial vein-finder and dual-point Photoplethysmogram (2PPG) has resulted in 4 TDs and another patent on “IoT enabled EPCG-device-unit for nursing heart-health-distantly” with AusPat. Office. He has notable citations in the field of infrared physics & technology.
Ng was named the winner of the 2024 2nd IETI Ramesh Agarwal Lifetime Achievement Award in Science, Engineering or Technology. This award honors individuals with lifetime achievements in research, education, and service towards the advancement of any discipline of engineering and technology. The award committee quoted that the reason for his award is: For outstanding contributions in non-invasive, contactless, early detection of human health abnormality economically with infrared physics technology & advanced AI novel analysis.

Abstract: Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), and it is a risk factor for insulin resistance/type 2 diabetes, hypertension, and cardiovascular diseases. However, the mechanisms linking IH and the diseases remain elusive. We used in vitro IH system to expose pancreatic β-cells, adipocytes, hepatocytes, skeletal muscle cells, neuronal cells, enteroendocrine cells, vascular smooth muscle cells, vascular endothelial cells, juxtaglomerular cells, cardiomyocytes to IH or normoxia for analyzing changes of gene expression and the mechanisms. We found that IH induced (1) attenuation of glucose-induced insulin secretion via downregulation CD38, (2) upregulation of adipokines via downregulation of microRNA (miR)-452, (3) upregulation of hepatokine via downregulation of miR-203, (4) upregulation of myokines via OCT1- and NRF2-mediated mechanism, (5) vascular smooth muscle cell proliferation via upregulation of EGF family, (6) upregulation of ESM1 and ICAM-1 in vascular endothelial cells via downregulation of miR-181a1, (7) upregulation of renin in juxtaglomerular cells via downregulation of miR-203, (8) upregulation of catecholamine-metabolizing enzymes in catecholamine synthesizing neuronal cells via downregulation of miR-375, and (9) downregulation of components for the CD38-cyclic ADP-ribose signal system in cardiomyocytes via upregulation of Pten. In SAS, cells throughout the body are exposed to IH, which affects various cells related to diabetes, hypertension, and heart disease, which are complications frequently seen in SAS. We have clarified the effects of IH exposure through molecular biological methods. In the future, it will be important to develop good animal models and use them to develop treatment and prevention methods.
Keywords: diabetes, hypertension, SAS, IH, CD38-cADPR signal system, Reg-Reg receptor system

Biography: Shin Takasawa was born in 1958 in Kashiwazaki, Nigata, Japan. He qualified as a medical doctor at the age of 25 years in Yamagata University and has completed his PhD at the age of 30 years from Tohoku University School of Medicine. He has been engaged in biochemical and molecular biological research on diseases such as diabetes in Tohoku University Graduate School of Medicine as a staff of Department of Biochemistry. In the process, he found cyclic ADP-ribose as a second messenger in glucose-induced insulin secretion from pancreatic β-cells and Reg (regenerating gene)-Reg receptor system in β-cell regeneration. In 2007, he moved to professor & chairman of Department of Biochemistry, Nara Medical University and performed molecular research concerning sleep apnea syndrome (SAS)/intermittent hypoxia (IH). He has published more than 200 papers in reputed journals and has been serving as an editorial board member of Life Sci. & Int. J. Mol. Sci.